A catalyst-free, photochemical flow cyclopropanation makes its debut in Green Chem.!
The reaction is scalable, safe and sustainable - proceeding in biodegradable dimethylcarbonate solvent - to afford up to grams per hour of densely-functionalized cyclopropanes as valuable intermediates in natural product and pharmaceutical synthesis. It exemplified nicely the power of Design of Experiments to get us to the reaction condition 'sweet spot', in just two afternoons of research.
Viktor did a terrific job with this and it was a true pleasure to supervise him on this project. We thank AK Reiser for the fruitful collaboration!
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